1.      Chen, Y.W., Chou, H.C., Lyu, P.C., Yin, H.S., Huang, F.L., Chang, W.S.W., Fan, C.Y., Tu, I.F., Lai, T.C., Lin, S.T., Lu, Y.C., Wu, C.L., Huang, S.H. and Chan, H.L.* (2011). “Mitochondrial proteomics analysis of tumorigenic and metastatic breast cancer markers.” Functional and Integrative Genomics. (in press). (*corresponding author).

2.      Hung, P.H., Lu, Y.C., Chen, Y.W., Chou, H.C., Lyu, P.C., Lee, Y.R. and Chan, H.L.* (2011). “Proteomic identification of plasma signatures in type 2 diabetic nephropathy.” Journal of Integrated OMICS 1: 151-156. (*corresponding author).

3.      Hung, P.H., Chen, Y.W., Cheng, K.C., Chou, H.C., Lyu, P.C., Lu, Y.C., Lee, Y.R., Wu, C.T. and Chan, H.L.* (2011). “Plasma Proteomic Analysis of the Critical Limb Ischemia markers in Diabetic Patients with Hemodialysis.” Molecular Biosystems. (in press). (*corresponding author).

4.      Chuang, C.S. Pai, T.W., Hu, C.H., Tzou, W.S., Chang, M. D.T., Chang, H.T., Chen, C.C. (2011) “Functional pathway mapping analysis for hypoxia-inducible factors. ” BMC Syst. Biol. 5, Suppl. 1:S3.

1.      Worthington, J., Bertani, M., Chan, H.L., Gerrits, B. and Timms, J.F. (2010). “Transcriptional profiling of ErbB signalling in mammary luminal epithelial cells - interplay of ErbB and IGF1 signalling through IGFBP3 regulation.” BMC Cancer 10: 490.

2.      Lai, T.C., Chou, H.C., Chen, Y.W., Lee, T.R., Chan, H.T., Shen, H.H., Lee, W.T., Lin, S.T., Lu, Y.C., Wu, C.L. and Chan, H.L.* (2010). “Secretomic and Proteomic Analysis of Potential Breast Cancer Markers by Two-Dimensional Differential Gel Electrophoresis.” Journal of Proteome Research 9(3): 1302-1322. (*corresponding author).

3.      Lai, C.H., Chang, N.W., Lin, C.F., Lin, C.D., Lin, Y.J., Wan, L., Sheu, J.J.C., Chen, S.Y., Huang, Y.P., Sing, Y.T., Tao, T.W., Lai, C.K., Tsai, M.H., Chan, H.L., Jou, Y.J. and Lin, C.W. (2010). “Proteomics-based identification of haptoglobin as a novel plasma biomarker in oral squamous cell carcinoma.” Clinica Chimica Acta 411(13-14): 984-991.

4.      Huang, H.L., Hsing, H.W., Lai, T.C., Chen, Y.W., Lee, T.R., Chan, H.T., Lyu, P.C., Wu, C.L., Lu, Y.C., Lin, S.T., Lin, C.W., Lai, C.H., Chang, H.T., Chou, H.C. and Chan, H.L. (2010). “Trypsin-induced proteome alteration during cell subculture in mammalian cells.” Journal of Biomedical Science 17(1): 36.

5.      Chou, H.C., Chen, Y.W., Lee, T.R., Wu, F.S., Chan, H.T., Lyu, P.C., Timms, J.F. and Chan, H.L.* (2010). “Proteomics study of oxidative stress and Src kinase inhibition in H9C2 cardiomyocytes: a cell model of heart ischemia-reperfusion injury and treatment.” Free Radical Biology and Medicine 49(1): 96-108. (*corresponding author).

6.      Chan, H.L., Chou, H.C., Duran, M., Gruenewald, J., Waterfield, M.D., Ridley, A. and Timms, J.F. (2010). “Major Role of Epidermal Growth Factor Receptor and Src Kinases in Promoting Oxidative Stress-dependent Loss of Adhesion and Apoptosis in Epithelial Cells.” Journal of Biological Chemistry 285(7): 4307-4318.

7.      Hubner, N.C., Wang, L.H.C., Kaulich, M., Descombes, P., Poser, I. and Nigg, E. A. (2010). “Re-examination of siRNA specificity questions role of PICH and Tao1 in the spindle checkpoint and identifies Mad2 as a sensitive target for small RNAs.” Chromosoma 119(2): 149-165.

8.      Wang, L.H.C.*, Mayer, B., Stemmann, O., and Nigg, E.A. (2010). “Centromere DNA decatenation depends on separase activation and is required for mammalian cell division.” Journal of Cell Science 123, 806-813. (*corresponding author).

9.      Yan, K.H., Yao, C.J., Chang, H.Y., Lai, G.M., Cheng, A.L. and Chuang, S.E. (2010). “The Synergistic Anticancer Effect of Troglitazone Combined With Aspirin Causes Cell Cycle Arrest and Apoptosis in Human Lung Cancer Cells.” Molecular Carcinogenesis 49(3): 235-246.

10. Wang, T.P., Pan, Y.R., Fu, C.Y. and Chang, H.Y.* (2010). “Down-regulation of UDP-glucose dehydrogenase affects glycosaminoglycans synthesis and motility in HCT-8 colorectal carcinoma cells.” Experimental Cell Research 316(17): 2893-2902. (*corresponding author).

11. Chen, J. C., Uang, B.J., Lyu, P.C., Chang, J.Y., Liu, K.J., Kuo, C.C., Hsieh, H.P., Wang, H.C., Cheng, C.S., Chang, Y.H., Chang, M.D.T.*, Chang, W.S.W. and Lin, C.C. (2010). “Design and Synthesis of alpha-Ketoamides as Cathepsin S Inhibitors with Potential Applications against Tumor Invasion and Angiogenesis.” Journal of Medicinal Chemistry 53(11): 4545-4549. (*corresponding author).

12. Chang, K.C., Lo, C.W., Fan, T.C., Chang, M.D.T., Shu, C.W., Chang, C.H., Chung, C.T., Fang, S.L., Chao, C.C., Tsai, J.J. and Lai, Y.K. (2010). “TNF-alpha Mediates Eosinophil Cationic Protein-induced Apoptosis in BEAS-2B Cells.” BMC Cell Biology 11: 6.

13. Liu, C.C., Liu, J.H., Wu, S.C., Yen, C.C., Chen, W.S. and Tsai, Y.C. (2010). “A Novel E1B-55kD-Deleted Oncolytic Adenovirus Carrying Mutant KRAS-Regulated hdm2 Transgene Exerts Specific Antitumor Efficacy on Colorectal Cancer Cells.” Molecular Cancer Therapeutics 9(2): 450-460.

14. Chen, J.C., Uang, B.J., Lyu, P.C., Chang, J.Y., Liu, K.J., Kuo, C.C., Hsieh, H.P., Wang, H.C., Cheng, C.S., Chang, Y.H., Chang, M.D.T., Chang, W.S.W. and Lin, C.C. (2010). “Design and Synthesis of alpha-Ketoamides as Cathepsin S Inhibitors with Potential Applications against Tumor Invasion and Angiogenesis.” Journal of Medicinal Chemistry 53(11): 4545-4549.

15. Kasiappan, R., Shih, H.J., Wu, M.H., Choy, C.O., Lin, T.D., Chen, L.. and Hsu, H.L. (2010). “The antagonism between MCT-1 and p53 affects the tumorigenic outcomes.” Molecular Cancer 9: 11.

16. Young, S. C., Chang, L.W., Lee, H.L., Tsai, L.H., Liu, Y.C. and Lin, P.P. (2010). “DNA Damage Induced by trans, trans-2,4-Decadienal (tt-DDE), a Component of Cooking Oil Fume, in Human Bronchial Epithelial Cells.” Environmental and Molecular Mutagenesis 51(4): 315-321.

17. Yen, C.Y., Chiu, C.C., Chang, F.R., Chen, J.Y.F., Hwang, C.C., Hseu, Y.C., Yang, H.L., Lee, A.Y.L., Tsai, M.T., Guo, Z.L., Cheng, Y.S., Liu, Y.C., Lan, Y.H., Chang, Y.C., Ko, Y.C., Chang, H.W. and Wu, Y.C. (2010). “4 beta-Hydroxywithanolide E from Physalis peruviana (golden berry) inhibits growth of human lung cancer cells through DNA damage, apoptosis and G(2)/M arrest.” BMC Cancer 10.

18. Chou, H.C., Chen, Y.W., Lee, T.R., Wu, F.S., Chan, H.T., Lyu, P.C., Timms, J.F. and Chan, H.L. (2010). “Proteomics study of oxidative stress and Src kinase inhibition in H9C2 cardiomyocytes: a cell model of heart ischemia-reperfusion injury and treatment.” Free Radical Biology and Medicine 49(1): 96-108.

19. Wang, C.H., Su, P.T., Du, X.Y., Kuo, M.W., Lin, C.Y., Yang, C.C., Chan, H.S., Chang, S.J., Kuo, C., Seo, K., Leung, L.L. and Chuang, Y.J. (2010). “Thrombospondin Type I Domain Containing 7A (THSD7A) Mediates Endothelial Cell Migration and Tube Formation.” Journal of Cellular Physiology 222(3): 685-694.

20. Hsu, R.M., Tsai, M.H., Hsieh, Y.J., Lyu, P.C. and Yu, J.S. (2010). “Identification of MYO18A as a Novel Interacting Partner of the PAK2/beta PIX/GIT1 Complex and Its Potential Function in Modulating Epithelial Cell Migration.” Molecular Biology of the Cell 21(2): 287-301.

21. Hsieh, Y.J., Yu, J.S. and Lyu, P.C. (2010). “Characterization of Photodynamic Therapy Responses Elicited in A431 Cells Containing Intracellular Organelle-Localized Photofrin.” Journal of Cellular Biochemistry 111(4): 821-833.

22. Pan, T.L., Hung, Y.C., Wang, P.W., Chen, S.T., Hsu, T.K., Sintupisut, N., Cheng, C.S. and Lyu, P.C. (2010). “Functional proteomic and structural insights into molecular targets related to the growth inhibitory effect of tanshinone IIA on HeLa cells.” Proteomics 10(5): 914-929.

1.      Lee, C. F., Ling, Z.Q., Zhao, T., Fang, S.H., Chang, W.C., Lee, S.C. and Lee, K.R.* (2009). “Genomic-wide analysis of lymphatic metastasis-associated genes in human hepatocellular carcinoma.” World Journal of Gastroenterology 15(3): 356-365. (*corresponding author).

2.      Lee, J.L., Wang, M.J. and Chen, J.Y. (2009). “Acetylation and activation of STAT3 mediated by nuclear translocation of CD44.” Journal of Cell Biology 185(6): 949-957.

3.      Saunter, C.D., Perng, M.D., Love, G.D. and Quinlan, R.A. (2009). “Stochastically determined directed movement explains the dominant small-scale mitochondrial movements within non- neuronal tissue culture cells.” Febs Letters 583(8): 1267-1273.

4.      George, R., Chan, H.L., Ahmed, Z., Suen, K.M., Stevens, C.N., Levitt, J.A., Suhling, K., Timms, J. and Ladbury, J.E. (2009). “A complex of Shc and Ran-GTPase localises to the cell nucleus.” Cellular and Molecular Life Sciences 66(4): 711-720.

5.      Duran, M.C., Chan, H.L. and Timms, J.F. (2009). “Identification of oxidative stress-induced tyrosine phosphorylated proteins by immunoprecipitation and mass spectrometry.” Methods in Molecular Biology 527: 33-45.

6.      Wu, J.M., Jan, P.S., Yu, H.C., Haung, H.Y., Fang, H.J., Chang, Y.I., Cheng, J.W. and Chen, H.M. (2009). “Structure and function of a custom anticancer peptide, CB1a.” Peptides 30(5): 839-848.

7.      Huang, Y.F., Chang, M.D.T. and Shieh, S.Y. (2009). “TTK/hMps1 Mediates the p53-Dependent Postmitotic Checkpoint by Phosphorylating p53 at Thr18.” Molecular and Cellular Biology 29(11): 2935-2944.

8.      Lo, C.W., Chang, Y.S., Chao, C.C., Chang, M.D.T., Chang, K.C. and Lai, Y.K. (2009). “Control Mechanisms of Differential Translation of Hsp90 Isoforms in 9L Rat Gliosarcoma Cells.” Journal of Cellular Biochemistry 107(3): 418-427.

9.      Chiu, C.C., Chang, H.W., Chuang, D.W., Chang, F.R., Chang, Y.C., Cheng, Y.S., Tsai, M.T., Chen, W.Y., Lee, S.S., Wang, C.K., Chen, J.Y.F., Wang, H.M., Chen, C.C., Liu, Y.C.* and Wu, Y.C. (2009). “Fern Plant-Derived Protoapigenone Leads to DNA Damage, Apoptosis, and G(2)/M Arrest in Lung Cancer Cell Line H1299.” DNA and Cell Biology 28(10): 501-506. (*corresponding author).

1.      Lee, J.L., Wang, M.J., Sudhir, P.R. and Chen, J.Y. (2008). “CD44 engagement promotes matrix-derived survival through the CD44-Src-integrin axis in lipid rafts.” Molecular and Cellular Biology 28(18): 5710-5723.

2.      Perng, M.D., Wen, S.F., Gibbon, T., Middeldorp, J., Sluijs, J., Hol, E.M. and Quinlan, R.A. (2008). “Glial Fibrillary Acidic Protein Filaments Can Tolerate the Incorporation of Assembly-compromised GFAP-delta, but with Consequences for Filament Organization and alpha B-Crystallin Association.” Molecular Biology of the Cell 19(10): 4521-4533.

3.      Wang, L.H.C., Schwarzbraun, T., Speicher, M.R. and Nigg, E.A. (2008). “Persistence of DNA threads in human anaphase cells suggests late completion of sister chromatid decatenation.” Chromosoma 117(2): 123-135.

4.      Yang, Y.F., Chou, M.Y., Fan, C.Y., Chen, S.F., Lyu, P.C., Liu, C.C. and Tseng, T.L. (2008). “The possible interaction of CDA14 and protein elongation factor 1 alpha.” Biochimica Et Biophysica Acta-Proteins and Proteomics 1784(2): 312-318.

5.      Nishiwaki, T., Kobayashi, N., Iwamoto, T., Yamamoto, A., Sugiura, S., Liu, Y.C., Sarasin, A., Okahashi, Y., Hirano, M., Ueno, S. and Mori, T. (2008). “Comparative study of nucleotide excision repair defects between XPD-mutated fibroblasts derived from trichothiodystrophy and xeroderma pigmentosum patients.” DNA Repair 7(12): 1990-1998.

6.      Chang, Y.C., Liao, C.B. Hsieh, P.Y.C., Liou, M.L. and Liu, Y.C.* (2008). “Expression of tumor suppressor p53 facilitates DNA repair but not UV-induced G2/M arrest or apoptosis in chinese hamster ovary CHO-K1 cells.” Journal of Cellular Biochemistry 103(2): 528-537. (*corresponding author).

7.      Chang, Y.C., Jan, K.Y., Cheng, C.A., Liao, C.B. and Liu, Y.C.* (2008). “Direct involvement of the tumor suppressor p53 in nucleotide excision repair.” DNA Repair 7(5): 751-761. (*corresponding author).

8.      Shu, C.V., Sun, F.C., Cho, J.H., Lin, C.C., Liu, P.F., Chen, P.Y., Chang, M.D.T., Fu, H.W. and Lai, Y.K. (2008). “GRP78 and Raf-1 cooperatively confer resistance to endoplasmic reticulum stress-induced apoptosis.” Journal of Cellular Physiology 215(3): 627-635.

9.      Hsiao, C.J., Li, T.K., Chan, Y.L., Hsin, L.W., Liao, C.H., Lee, C.H., Lyu, P.C. and Guh, J.H. (2008). “WRC-213, an L-methionine-conjugated mitoxantrone derivative, displays anticancer activity with reduced cardiotoxicity and drug resistance: Identification of topoisomerase II inhibition and apoptotic machinery in prostate cancers.” Biochemical Pharmacology 75(4): 847-856.

10. Chao, C.C., Sun, F.C., Wang, C.H., Lo, C.W., Chang, Y.S., Chang, K.C., Chang, M.D.T. and Lai, Y.K. (2008). “Concerted actions of multiple transcription elements confer differential Transactivation of HSP90 isoforms in geldanamycin-treated 9L rat gliosarcoma cells.” Journal of Cellular Biochemistry 104(4): 1286-1296.

11. Hsiao, C.J., Ho, Y.F., Hsu, J., Chang, W.L., Chen, Y.C., Shen, Y.C., Lyu, P.C. and Guh, J.H. (2008). “Mana-Hox displays anticancer activity against prostate cancer cells through tubulin depolymerization and DNA damage stress.” Naunyn-Schmiedebergs Archives of Pharmacology 378(6): 599-608.